DNA repair mechanisms role in survival to nucleoside analogues Thesis

DNA repair mechanisms role in survival to nucleoside analogues preaching in S.pombe - Thesis ExampleTwo methods of treatment where this is especially important to consider are topoisomerase inhibitors and nucleoside analogues. In both of these cases, DNA repair systems involve the use of the Mre11/Rad50/NBS1 complex. This project aims to examine how DNA repair mechanisms of genus Schizosaccharomyces pombe contribute to fortress to treatment with nucleoside analogues. This information should help to provide further insight into the way in which human cells are able to develop resistance to this form of treatment, and perhaps provide some indication of a method to prevent this.In everyday life, cells are exposed to external and internal agents that incur thousands of DNA mutations per day. These mutations range from being small, such as affecting a single nucleotide, to large mutations where accurate repair can be difficult. For the accurate filename extension of the genetic inform ation within cells, it is essential that the body has mechanisms of repairing damage in a reliable manner. However, while many methods for DNA repair exist, these are not always successful and mutations can accumulate, resulting in the development of cancer (Helleday et al., 2007). Understanding these processes, why they occur the way that they do and what can be done to make up ones mind these is crucial for knowing the way that cancer occurs, and determining methods of treating it effectively.In our modern society, cancer has remained one of the most well studied diseases and perhaps one of the to the lowest degree understood. The fundamental aspects of cancer are damage in the DNA of a cell that results in a lack of control over cell reaping and replication, as well reducing the likelihood that cells will enter apoptosis. These cells are able to proliferate well beyond the normal constraints of the tissue that they are in (Loeb et al., 2003). With high levels of replication an d low cell death, abnormal cells build up